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Monday, June 24, 2019

The cause of death of King Rajasinghe of Sithawake, Ceylon in 1593

Analysis of the reported symptoms that preceded the death of KingRajasinghe of Sithawake (1593 AD)

ArticleinCeylon Medical Journal 47(2):65-7 · July 2002with 16 Reads
DOI: 10.4038/cmj.v47i2.3458 · Source: PubMed
Cite this publication
Abstract
A copy of an ola leaf manuscript, the original of which was written around the late 1590s, was published recently. It describes the sequence of events leading to the death of the warrior King Rajasinghe of the Sithawake Kingdom (1521-1593). A study of the contents of this letter is presented. The dressing applied to a wound on the foot of the King is described in that letter. It is likely that this dressing would have been an ideal medium to produce the highly potent tetanus exotoxin. The toxin would have diffused into the open wound and produced the sequence of symptoms and signs mentioned in the letter. An analysis of the symptoms and signs noted during the King's last illness as described in the letter is presented. Laryngospasm, and tonic and clonic spasms are easily identified. In addition, a group of symptoms attributed in the 1960s to sympathetic over-activity in tetanus are also recognisable. The conclusion is drawn that the King died of tetanus. The intriguing possibility of the wilful use of a lethal dressing on an open wound as a biological contact poison is left open for discussion.
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Saturday, June 22, 2019

Coconut oil, WADL Amarasiri, AS Dissanayake,


Title page

Title                                                                 :           Coconut fats - a perspective

Authors                                                           :           1. Dr. W. A. D. L. Amarasiri 1
                                                                                    2. Dr. A. S. Dissanayake 2
                                   
Author for correspondence
                                    :           Dr. W. A. D. L. Amarasiri
                                                Lecturer
                                                Department of Physiology
                                                Faculty of Medicine
                                                University of Kelaniya
                                                P.O. Box 6, Thalagolla Road,
Ragama.
                                      
        Tel: 0777 449 866, 0112 958219 ext 28

All reprint requests could be directed to the above address.

Number of words in manuscript                    :           2026


Abstract
In many areas of Sri Lanka the coconut tree and its products have been an integral part of rural life and it come to be called the “Tree of Life”.
Coconut fats (CF) account for 80% of the fat intake among Sri Lankans. Around 92% of coconut fats are saturated fats. This has lead to the belief that coconut fats are ‘bad for health’ particularly in relation to ischaemic heart disease. Yet, most of the saturated fats in coconut are medium chain fatty acids whose properties and metabolism are different to those of animal origin.  The relationship between coconut fats and health has been the subject of much debate and misinformation.
The main fatty acid in CF is lauric acid (LA).  The only other naturally occurring fat with high LA content is human breast milk. This begs the question whether CFs  do have beneficial effects. 
There is the need to clarify issues relating to intake of coconut fats and health more particularly for populations that still depend on coconut fats for much of their fat intake. This paper describes the metabolism of coconut fats and its potential benefits, and attempts to highlight its benefits in order to remove certain misconceptions regarding its use. …
…Coconut trees were known to have existed as far back as 161 BC and the existence of coconut plantations was first recorded in the 2nd Century AD. Coconut kernel and kernel products such as coconut milk and coconut oil (CO) are eaten mainly for the exquisite taste that the fats in coconut convey to food.

Fats make up less than 25% of the total energy expenditure among Sri Lankans. Studies done more than 20-30 years back have shown that coconut fats constitutes about 80% or more of the total fat intake of Sri Lankans [1].
Over 95% of coconut oil is fat while the fat content of scraped coconut is around 34% and that of coconut milk around 20%. It is also true that around 92% of the coconut fat is saturated fat [2].  However, the saturated fats in coconut and palm-kernel oil also called “tropical oils” differ from saturated fats in animal fats. Over 50% of the fats in coconut are medium chain triglycerides that are formed from fatty acids of chain length 8:0 to 14:0. It is primarily the 14:0 fatty acids that are thought to be atherogenic.  When digested in the small intestine, these yield saturated medium chain free fatty acids and monoglycerides. Lauric acid and monolaurin constitute around 50% of CF derived lipid.  However unlike long chain fatty acids, these medium chain free fatty acids and monoglycerides are absorbed intact from the small intestine and do not undergo degradation and re-esterification processes.
They are directly utilized in the body to produce energy and are therefore widely used in infant formulas, nutritional drinks for athletes and in intravenous lipid infusions. Animal and human studies have shown that the fast rate of oxidation of medium chain free fatty acids leads to greater energy expenditure. Animal studies have also demonstrated that this greater energy expenditure results in less body weight gain and decreased size of fat depots after several months of consumption. Furthermore, both animal and human trials suggest a greater satiating effect of medium-chain triglycerides compared with long-chain triglycerides [3].  In fact, administration of medium-chain triglycerides in the form of coconut oil along with a saturated fat diet increased oxidation of long-chain fatty acids in the body [4].


Current understanding based on the effect of dietary lipid manipulation upon immune system function indicates that fatty acids are involved in the modulation of the immune response through different and complex pathways. The problem with many animal studies is that they use hydrogenated coconut oil. One study where non hydrogenated coconut oil was used showed that lipopolysaccharide-stimulated TNF-alpha production by macrophages decreased with increasing unsaturated fatty acid content of the diet [24]. There are anecdotal claims to the effect that using coconut oil improves the action of anti-HIV drugs. Many other unsubstantiated claims on the benefits of coconut products such as its anti-oxidant effects etc, are gaining popularity among health food enthusiasts.

Clearly more work both of an epidemiological and experimental nature need to be done to establish whether coconut fats are indeed associated with the atherogenesis, ischaemic heart disease and cerebro-vascular disease. Population studies should attempt to remove the possible effect of other confounding variables such as increased consumption of animal fats along with coconut, smoking, alcohol more particularly illicit brews that could contribute to the increasing incidence of ischaemic heart disease and cerebro-vascular disease in Sri Lanka. In the absence of convincing evidence both epidemiological and experimental against the continued use of coconut fats in relation to atherosclerosis and ischaemic heart disease, one has to ask whether the recommendation of the Asian Heart Assoication issued in 1996, An intake of 400 g/day fruit, vegetables and legumes, mustard or soybean oil (25 g/day) instead of hydrogenated fat, coconut oil or butter in conjunction with moderate physical activity (1255 kJ/day), cessation of tobacco consumption and moderation of alcohol intake may be an effective package of remedies for prevention of coronary artery disease in Asians” is valid in toto[25]. Should we be encouraging the use of mustard, soybean, corn or sunflower oils all of which will need to be imported or emphasize the need for eliminating smoking, excessive use of alcohol, animal fats and other life-style changes instead?

Honorary Fellowship of the Royal College of Psychiatrists.


Psychiatric Bulletin (2003) 27: 471-472
© 2003 
The Royal College of Psychiatrists 

The College
Dr Pearl D. J. Hettiaratchy
(Introduced by Professor Susan Benbow)
Dr Pearl Hettiaratchy is a distinguished clinician, doctor, psychiatrist and old age psychiatrist, who has contributed to the National Health Service (NHS) over a period of more than 30 years. She qualified in Sri Lanka, one of three family members who took up medicine: her brother was a physician and her sister Port Health Officer in Colombo.
She came to the United Kingdom in 1968 for a clinical attachment at St James Hospital, Portsmouth, where she later commenced her first consultant appointment in 1975 after completing her training. Here, together with a nurse manager colleague, she pioneered the development of old age psychiatry services, setting up the first travelling day hospital for older people in the UK.
She has enthused colleagues of all disciplines, and educated people from many backgrounds to reflect on and improve their practice. For 5 years from 1983 to 1987, she single-handedly ran the Region’s Day Release Courses in the Psychiatry of Old Age, and educated 400-500 key professionals, who are now leading old age psychiatry services regionally and nationally. She moved to Winchester in 1984, where she continued to teach and develop services.
Pearl has worked for the Royal College of Psychiatrists on committees concerning later life, nursing, ethnic issues and unethical practices, and has also served as Vice President. She has been an important role model for younger people coming into the specialty. She was featured as one of five psychiatrists giving their views on why psychiatry is a rewarding career to choose, in the College’s career information pack produced in 1990, and again in 1994. What she wrote here is typical of Pearl’s approach to her work:
‘the field of psychiatry fascinates me. It takes time, patience and diligence to unravel the workings of the human mind and one can never fully understand its intricacies. Every patient I see, even after 23 years’experience is still a diagnostic puzzle and a therapeutic challenge. So there can never be any burnout or boredom.’
And further:
‘At the core of psychiatry is the ability to empathise, understand and give something of yourself to the patient within thetherapeuticrelationship....’
Pearl has been determined and devoted to her work: her humanity and compassion are shown by her willingness to take unpopular stances when in the interests of her patients. Her advice wasoverruled during a ward closure in 1994 and eight elderly patients died shortly after moving from long-term hospital care into private nursing homes, against medical advice. The ensuing scandalled to guidance on long-term care, an ombudsman’s enquiry and a Select Committee hearing. Pearl was quoted in the press as saying:
‘the care team becomes the family of the patient. They are faces in their failing memories.’
She has worked tirelessly on behalf of older people in need of long-term care, unafraid of making her views known.
Pearl was elected to the General Medical Council (GMC)in 1994, and reelected in 1999. Her election was a great event in Sri Lanka, as she was the first Sri Lankan to serve on the GMC. Her reelection was reported in Island International on July 21 1999: the report noted that Pearl had participated in the discussions the GMC had with Sri Lanka’s Minister of Health in 1998 on holding the Professional and Linguistic Assessments Board test (part 1) in Sri Lanka. This was a landmark achievement and she has continued to work to support the development of services in Sri Lanka. With the GMC she has served on the Racial Equality Group, the Steering Group for Performance, the Professional Conduct Committee, the Standards Committee, and the Working Group on withholding and withdrawing life-prolonging treatment. She became Medical Screener for Conduct and Performance in 1997 and regularly investigates complaints against doctors.
She retired from clinical practice on 4 February 2002, after 34 years’ continuous service in the NHS, but later that year on 23 October, her work was recognised and honoured when she was invested OBE by Her Majesty the Queen at Buckingham Palace for services to old age psychiatry.
Pearl continues to be active in voluntary work, medico-legal work and medical politics. She is actively involved in national and local fora in influencing policy and decision making in the NHS, and her advice is respected on a range of subjects including the ethics of heath care, the support of doctors in difficulty and issues in multi-ethnic populations. Following the inquiry into the death of Stephen Lawrence, she has become involved in work with the Chief Medical Officer on racism in medicine, and is about to become an official role model for ethnic minority doctors. For many of us, she has been an unofficial role model for a number of years. One of the pleasures of her retirement is to be able to spend more time with her family, especially her six grandchildren.
Pearl is a valued, loved and respected psychiatrist and old age psychiatrist. I am delighted to present her for the Honorary Fellowship of the Royal College of Psychiatrists.

Thursday, June 20, 2019

Reminiscences of the 1960 entrants batch reunions


Please click on each underlined web-link below with your speakers on :-

Medical entrants 1960, Kynsey road, Colombo, Sri Lanka.

25th year after passing out reunion – Kandy

Geris dancing couple

Geri – One armed fiddler

Funeral of Sarath Kapuwaththe

Habarana reunion

Lodge dinner at Habarana

Get together - Negombo


    Memorable poems
 of our schooldays
  
    Soft launch of a book

    CoMSAA - Mini get together of the batch

    Jayadewi - Interview